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Hyperglycemia, hypercreatinemia, hyperkalemia, and hyponatremia all occurred significantly more frequently among patients receiving dexamethasone than among those receiving placebo.

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The safety and efficacy of Ninlaro were demonstrated in an international, randomized, double-blind clinical trial of 722 patients whose multiple myeloma came back after, or did not respond to, previous treatment.

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Barbiturates, phenytoin, and rifampin may enhance metabolism; may need to increase corticosteroid dose.

Review boards at all the participating institutions approved the study, and all patients provided written informed consent.

The treatment was well tolerated.

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Blood cortisol testing evaluates both protein-bound and free cortisol while urine and saliva testing evaluate only free cortisol, which should correlate with the levels of free cortisol in the blood.

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Thus combining bortezomib with cyclophosphamide and dexamethasone in the CyBorD regimen takes advantage of an alkylator yet allows adequate stem cell collection in all patients at relatively low cost.

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This study compared the efficacy and safety of high-dose dexamethasone (HD-DXM) and conventional prednisone (PDN) on the largest cohort to date as first-line strategies for newly diagnosed adult primary immune thrombocytopenia (ITP).

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Each patient will be randomly allocated to receive either oral dexamethasone or an identical appearing placebo tablet for two days after chemotherapy for the first cycle of chemotherapy, and then crossed over to the other treatment for the second cycle.

Dosages of prednisone between 40 and 80 mg per day can be used.

The proportion of patients with focal neurologic deficit by nine months and the frequency of adverse events were compared with the use of the chi-square test.

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Three cohorts are reported; optimal dose of carfilzomib is not described.

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Administration of high dosages of medications containing this preservative must take into account the total amount of benzyl alcohol administered.

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